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Leucettine L41
CAS No. 112978-84-3
Leucettine L41( Leucettine L41 | Leucettine-L41 | LeucettineL41 )
Catalog No. M10457 CAS No. 112978-84-3
A novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameLeucettine L41
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively.
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DescriptionA novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively; inhibits the phosphorylation of serine/arginine-rich proteins (SRp), a family of proteins regulating pre-RNA splicing, modulates alternative pre-mRNA splicing in cell-based reporting system; induces mTOR-dependent autophagy, prevents Aβ25-35-induced memory impairments and neurotoxicity in the mouse hippocampus.
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In Vitro——
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In Vivo——
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SynonymsLeucettine L41 | Leucettine-L41 | LeucettineL41
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PathwayCell Cycle/DNA Damage
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TargetCLK
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RecptorCLK
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Research Area——
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Indication——
Chemical Information
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CAS Number112978-84-3
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Formula Weight307.309
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Molecular FormulaC17H13N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1NC(NC2=CC=CC=C2)=N/C1=C\C3=CC=C(OCO4)C4=C3
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Chemical Name(5Z)-5-(1,3-Benzodioxol-5-ylmethylene)-3,5-dihydro-2-(phenylamino)-4H-imidazol-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fant X, et al. Mol Pharmacol. 2014 Mar;85(3):441-50.
2. Naert G, et al. Eur Neuropsychopharmacol. 2015 Nov;25(11):2170-82.
3. Debdab M, et al. J Med Chem. 2011 Jun 23;54(12):4172-86.
4. Tahtouh T, et al. J Med Chem. 2012 Nov 8;55(21):9312-30.
molnova catalog
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Leucettine L41
A novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively.
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Leucettamine B
Leucettamine B is a potent inhibitor of CLK1 (IC50=15 nM), Dyrk1A (IC50=40 nM), and Dyrk2 (IC50=35 nM) and a moderate inhibitor of CLK3 (IC50=4.5 uM).
