Leucettine L41

CAS No. 112978-84-3

Leucettine L41 ( Leucettine L41; Leucettine-L41; LeucettineL41 )

Catalog No. M10457 CAS No. 112978-84-3

A novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Leucettine L41
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively.
  • Description
    A novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively; inhibits the phosphorylation of serine/arginine-rich proteins (SRp), a family of proteins regulating pre-RNA splicing, modulates alternative pre-mRNA splicing in cell-based reporting system; induces mTOR-dependent autophagy, prevents Aβ25-35-induced memory impairments and neurotoxicity in the mouse hippocampus.
  • Synonyms
    Leucettine L41; Leucettine-L41; LeucettineL41
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    CLK
  • Recptor
    CLK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    112978-84-3
  • Formula Weight
    307.31
  • Molecular Formula
    C17H13N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1NC(NC2=CC=CC=C2)=N/C1=C\C3=CC=C(OCO4)C4=C3
  • Chemical Name
    (5Z)-5-(1,3-Benzodioxol-5-ylmethylene)-3,5-dihydro-2-(phenylamino)-4H-imidazol-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fant X, et al. Mol Pharmacol. 2014 Mar;85(3):441-50.
2. Naert G, et al. Eur Neuropsychopharmacol. 2015 Nov;25(11):2170-82.
3. Debdab M, et al. J Med Chem. 2011 Jun 23;54(12):4172-86.
4. Tahtouh T, et al. J Med Chem. 2012 Nov 8;55(21):9312-30.
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